• Laminin 925-933 A third motif involves the toggle

  2023-04-25

  

  A third motif involves the toggle switch and consists of the conserved FxxCWxP sequence in TM6 of class A GPCRs (Hofmann et al., 2009, Rosenbaum et al., 2009). Rotamerization of Trp in combination with a kink caused by Pro facilitates the outward movement of TM6 upon activation (Hofmann et al., 2009

• br Conclusion br Acknowledgements br Introduction Synapses a

  2023-04-25

  

  Conclusion Acknowledgements Introduction Synapses are the fundamental elements of neuronal networks that enable the processing, encoding, and retrieval of information in the brain, and pathological disruptions in synapse structure are broadly held to underlie the development of neurological

• Previous investigations have established that

  2023-04-25

  

  Previous investigations have established that aromatase activity is regulated via two different pathways in a tissue-specific manner. The first is a slower transcription regulatory pathway that involves an alteration in gene transcription and represents what is classically thought of as the way by w

• Our previous studies and others have identified that

  2023-04-25

  

  Our previous studies and others have identified that the inhalational anesthetic isoflurane induces neuronal apoptosis via [Ca2+]i overload through the opening of synaptic voltage-dependent calcium channels (VDCCs) and the excessive Ca2+ release from the endoplasmic reticulum (Zhao et al., 2011; Zha

• br Findings br Discussion br Conclusions

  2023-04-25

  

  Findings Discussion Conclusions Midwives were more likely to provide effective antimalaria services (including two doses of IPT during the second and third trimesters of pregnancy) to pregnant women if Conflict of interest Authors’ contributions Funding Acknowledgements Resea

• To date attention has been directed towards

  2023-04-25

  

  To date, attention has been directed towards new molecular targets in luminal phenotype (ER-positive), such as CDK4/6 and, to a lesser extent, androgen receptor (AR) pathways [8]. While the role of CDK4/6 has been elucidated and their inhibitors have shown a benefit in luminal BC, the role of AR in

• Structural and functional imaging studies searching for spec

  2023-04-25

  

  Structural and functional imaging studies searching for specific cortical areas related to each cognitive function domain have provided clues to the spreading patterns of cognitive dysfunction (Domoto-Reilly et al., 2012, Firbank et al., 2016, Li et al., 2012, Machulda et al., 2003, Mandal et al., 2

• br The prevalence of diabetes is increasing globally and the

  2023-04-25

  

  The prevalence of diabetes is increasing globally, and the situation is particularly alarming in Asia. The prevalence of diabetes in China has increased dramatically, from around 1% in 1980 to the most recent estimate of 9.7% according to a nationwide survey . Cumulative evidence shows that type 2

• Inhibition of autophagy has been shown to

  2023-04-25

  

  Inhibition of autophagy has been shown to alleviate neuronal damage after cerebral ischemia, both in cell culture and rodent models (Koike et al., 2008, Li et al., 2015, Wang et al., 2016, Zhang et al., 2014, Zheng et al., 2014). Therefore, blockage of autophagy is a potential target for prevention

• So far many independent studies have linked cholesterol

  2023-04-25

  

  So far, many independent studies have linked cholesterol metabolism–related genes with AD, either by showing associations with specific polymorphisms or with differential d mannitol levels (Beecham et al., 2014, Blain and Poirier, 2004, Lambert et al., 2009, Lambert et al., 2013, Leduc et al., 2015

• br Conflict of interest br Financial Support The work is

  2023-04-25

  

  Conflict of interest Financial Support The work is supported by research grants from Clinical Key Specialty Project of China and Clinical Medical Center of Suzhou, China (Szzx201502) and Jiangsu Province Special Program of Medical Science, China (BE2016672). Introduction Recently, function

• br Materials and methods br Results and

  2023-04-25

  

  Materials and methods Results and discussion First, we examined whether hypothalamic Akt-mediated signaling pathways are regulated postprandially in chickens. Refeeding significantly (P NMS-873 mg concentrations significantly increased in chicks after 1 h of refeeding (958 ± 245% of 24 h-fast

• br Discussion With recently improved understanding of the ro

  2023-04-25

  

  Discussion With recently improved understanding of the role of βARK1 in the progression of HF and as a potential therapeutic target in HF, we explored the relationship between plasma βARK1, as a marker of chronic sympathetic overactivation, and physical symptoms in HF. Our main findings were 1) e

• AdipoR and AdipoR have been reported

  2023-04-25

  

  AdipoR1 and AdipoR2 have been reported to be present in almost all type of tissues and low Olanzapine levels have been observed in white adipose tissue (Inukai et al., 2005). These receptors have been observed to become deregulated with the onset of obesity, resulting in a reduced level of APN expr

• Additionally in a previous transgenic model with autotaxin u

  2023-04-25

  

  Additionally, in a previous transgenic model with autotaxin under the control of the MMTV-LTR promoter, aberrant expression of human autotaxin caused late-onset, metastatic breast cancer [5]. The AT-ATX transgenic model is analogous to the previous one because ∼30% of all spontaneous tumors appeared

11059 records 13/738 page Previous Next First page 上5页 1112131415 下5页 Last page