• br Investigations br Genetics GLUT is a membrane bound glyco

  2022-04-20

  

  Investigations Genetics GLUT1 is a membrane-bound glycoprotein that provides base-rate glucose transport across blood-tissue barriers. It is constituitively expressed in erythrocytes, FK-228 microvessels and astroglia. The gene exclusively associated with GLUT1 is SLC2A1, located on chromosom

• br Acknowledgements br Introduction Benzodiazepine BZ treatm

  2022-04-20

  

  Acknowledgements Introduction Benzodiazepine (BZ) treatment is widely used for quick and efficient anxiolytic and sedative responses. However, when the use is extended to longer periods, adverse effects emerge. These include tolerance to the initial drug effect, dependence as revealed by withd

• The dorsal horn of the spinal cord

  2022-04-20

  

  The dorsal horn of the spinal cord shows a high density of Ca2+-permeable AMPA receptors, particularly in the superficial spinal laminae (laminae I and II), where primary afferents carrying nociceptive and thermoreceptive inputs terminate and synapse on spinal second-order neurons (Engelman et al.,

• Two pathways have emerged to explain the beneficial metaboli

  2022-04-19

  

  Two pathways have emerged to explain the beneficial metabolic effect of Roux-en-Y bypass [Fig. 3]. Firstly, the rapid delivery of nutrients to the distal small intestine and bowel might up-regulate secretion of a physiological stimulus that improves glucose homeostasis. As such, GLP-1 represents an

• Recently unimolecular multi functional peptides

  2022-04-19

  

  Recently, unimolecular, multi-functional peptides that combine GLP-1RA activity with LJI308 mg and/or GIP activity have been suggested as new therapeutic agents for glycaemic and weight control. In rodents, dual GIP and GLP-1 receptor agonists achieve significantly better glucose control and weight

• The first report about the activity of ANAM in CACs

  2022-04-19

  

  The first report about the activity of ANAM in CACs it is due to Garcia et al. [19] which treated 16 cancer patients with oral ANAM 50mg once daily vs placebo for 3days followed by a washout LiCl of 5–7days and then cross-over to the other group for 3 more days. It was described a weight gain of abo

• Minocycline HCl receptor Our own search towards aryl imidazo

  2022-04-19

  

  Our own search towards aryl-imidazole derived GSMs led to the discovery of the benzimidazole derivative (). It is one of the most potent GSMs to date, suffering however from sub-optimal drug-like properties. More recently, we have described the design and synthesis of bicyclic triazolo-derivatives,

• br Material and methods br Results and discussion

  2022-04-19

  

  Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass

• br Molecular mechanisms and pathways

  2022-04-19

  

  Molecular mechanisms and pathways for ferroptosis regulation As to the regulation of lipid peroxidation, iron and related ROS metabolism involved in ferroptosis, many molecular mechanisms and pathways have been presented. It is generally believed that cystine/glutamate antiporter system Xc−, GPX4

• Introduction RNA splicing occurs in

  2022-04-19

  

  Introduction RNA splicing occurs in the nucleus when noncoding sequences (introns) are removed from the pre-mRNA transcript and coding sequences (exons) are joined to form a mature mRNA [1,2]. This reaction is catalyzed by a multiprotein complex called spliceosome. The spliceosome consists of five

• Earlier we have showed that tumor associated sFas mRNA

  2022-04-19

  

  Earlier we have showed that tumor associated sFas mRNA isoform profile and splicing factors expression levels in solid tumors do not correspond to profiles that are observed in cell lines [45]. In the present study, for the first time we show that Fas but not Rac1 pre-mRNA's alternative splicing is

• br Anandamide signaling and cardiovascular function

  2022-04-19

  

  Anandamide signaling and cardiovascular function The cardiovascular effects of cannabinoid compounds have been known for a long time. Studies in humans indicate that chronic use of marijuana causes long lasting decrease in blood pressure and heart rate, whereas the acute use increases heart rate

• Hyperhomocysteinemia HHcy is a clinical

  2022-04-19

  

  Hyperhomocysteinemia (HHcy) is a clinical condition characterized by increased levels of plasma homocysteine (Hcy) and a well-known risk factor for CVDs. Hcy is a sulfur-containing non-protein amino salinomycin formed during the intracellular conversion of methionine to cysteine. Previous study demo

• HIV incidence is often determined by

  2022-04-19

  

  HIV incidence is often determined by following cohorts of HIV-uninfected individuals and quantifying the rate of new HIV infections. HIV incidence can also be estimated using a cross-sectional study design, using laboratory assays to identify individuals who are likely to have recent HIV infection.

• Recent studies in our laboratory demonstrated that several h

  2022-04-19

  

  Recent studies in our laboratory demonstrated that several histamine H1 receptor antagonists induce apo A-I gene expression while histamine itself represses it [20]. In humans, there are three histamine receptor genes (H1, H2, and H3) that code for G-protein-coupled receptors (GPCR's) which bind his

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