• br Family A Receptors as Promiscuous Sensors for

  2021-11-06

  

  Family A Receptors as Promiscuous Sensors for Peptone and Free Fatty Acids (FFAs) In addition to the family C 7TM receptors, several family A 7TM receptors are promiscuous in their ligand preferences, and several respond to organic nutrients from food, notably protein degradation products and FFA

• In the present study compared to

  2021-11-06

  

  In the present study, compared to diabetic control rats, hepatic glucose-6-phosphatase activity was significantly decreased in both SE and METF treated diabetic animals, with the latter producing greater reduction in glucose-6-phosphatase activity. This observation is consistent with the claim of Ta

• br Materials and methods br Results

  2021-11-06

  

  Materials and methods Results Discussion In this study, we discover that Sufu stabilizes Gli1 protein levels by antagonizing Numb/Itch-mediated protein degradation. Together with previous work that demonstrates control of Gli2/3 protein levels by Sufu (Chen et al., 2009, Jia et al., 2009, W

• The caseins are a family

  2021-11-06

  

  The caseins are a family of milk phosphoproteins whose biological function is to provide supersaturating concentrations of calcium, phosphates, and essential Reutericyclin australia to the neonate (Vonderhaar and Ziska, 1989). α- and β-caseins, the most abundant of the milk caseins, are described a

• Cx mimetic peptides short synthetic peptides corresponding t

  2021-11-06

  

  Cx mimetic peptides, short synthetic peptides corresponding to intracellular amino nmda antagonists sequences of diverse Cx have better specificity compared to traditional GJ blockers and openers. In particular, it was reported that Cx mimetic peptides reversibly inhibited GJ channel function in a c

• br Structures of human secretase Before the near

  2021-11-06

  

  Structures of human γ-secretase Before the near-atomic resolution structures, the highest resolutions achieved for γ-secretase were 15 and 12Å [19, 21]. The 15-Å structure revealed a Zerumbone chamber in the transmembrane domain and two pores at the top and bottom of γ-secretase, which were specu

• DLS only provides a Z average size based

  2021-11-06

  

  DLS only provides a Z-average size based on spherical model, hence the size of nanorods was determined as 300 nm by DLS measurement. However, the size of length is nearly 400 nm while width is about 100 nm, which was clearly observed by transmission electron microscopy (TEM) (D). Meanwhile, the TEM

• In mammalian cells Motins have been identified as a key

  2021-11-06

  

  In mammalian cells, Motins have been identified as a key link between F-actin and Hippo pathway regulation, as knockdown of all three Motins increased Yap activity even in the presence of cytoskeletal disruption [105]. Motins can physically associate with F-actin but this association is blocked by p

• br Notch Similar to the Wnt and

  2021-11-06

  

  Notch Similar to the Wnt and Hedgehog pathways as discussed earlier, Notch is an evolutionarily conserved primordial developmental pathway which affects patterning, and has an important role to play in cancer biology ranging from angiogenesis to cancer stem AY 9944 dihydrochloride to tumor immun

• Anti apoptotic Bcl proteins have become attractive targets

  2021-11-06

  

  Anti-apoptotic Bcl-2 proteins have become attractive targets for anti-cancer agents development, because they are associated with progression of a wide variety of human cancers., , The small-molecular Bcl-2 inhibitor venetoclax (ABT-199) () has been approved recently for the treatment of patients wi

• Racemic protein crystallography has been proven to be a powe

  2021-11-05

  

  Racemic protein crystallography has been proven to be a powerful technique for crystallizing proteins , , , , . The structures of many difficult-to-crystallize peptides/proteins of different sizes were resolved by the racemic protein crystallography combined with the protein chemical synthesis , , ,

• In this study we also

  2021-11-05

  

  In this study, we also investigated the role of GST Cyclosporin A in relation to ASD. In univariable analyses, where the role of each GST gene (i.e., GSTM1, GSTT1, GSTP1) was individually assessed, we did not observe any significant associations between the GST genotypes and ASD. In contrast, a pre

• Based on these findings we set out to identify

  2021-11-05

  

  Based on these findings, we set out to identify GPR109A agonists capable of biasing the receptor's signaling towards the functional anti-lipolytic and presumed therapeutic response, and away from the flushing side-effect pathways. Indeed, using recombinantly expressed GPR109A, two classes of compoun

• Following activation it is necessary

  2021-11-05

  

  Following activation, it is necessary for a subset of activated effector T cells to survive as long-lived memory T cells. Metabolically, this transition is dependent upon the ability of the cell to downregulate aerobic glycolysis and transition back to a more oxidative phenotype. In fact, enhancemen

• br Discussion CHO K cell

  2021-11-05

  

  Discussion CHO-K1 cell lines stably expressing each of the NH2-terminal isoforms of the human glycine reuptake transporter GlyT1 have been developed. GlyT1 uptake assays have been validated for two lines for each isoform, one low and high expressor. Expression levels in the lines have been confir

11114 records 249/741 page Previous Next First page 上5页 246247248249250 下5页 Last page