• br Results and Discussion br

  2021-03-15

  

  Results and Discussion Conclusion What we have shown here is that highly specific antagonist can be a very useful tool, can mimic gene KO experiments or even further dissect receptor function. We just took ETA antagonist as an example and found that ETA mediates physiological closure of DA whi

• The mechanisms by which coregulators

  2021-03-15

  

  The mechanisms by which coregulators control the actions of estrogen receptors are still a topic of ongoing research. From studies in cancer cells, we have learned that a large group of coregulators have specific structural motifs that than affect their contact with ER ligand-binding domains (Heery,

• RNA seq results also support the

  2021-03-15

  

  RNA-seq results also support the similarity between ESC- and YS-derived B-1 progenitors. Bmi1 expression, known as an important gene for self-renewal ability in stem cells, was reduced in ESC-derived B cells compared with YS-derived B cells, and Bmi1 overexpression improved the engraftment of ESC-de

• Introduction Hematopoietic stem cells HSCs in the adult bone

  2021-03-15

  

  Introduction Hematopoietic stem ptio receptor (HSCs) in the adult bone marrow (BM) provide all types of blood cells throughout life, while also self-renewing to maintain blood homeostasis. Blood/marrow stem cell transplantation is the most advanced method to cure patients suffering from hematologi

• br Introduction Receptor tyrosine kinases RTKs are criticall

  2021-03-15

  

  Introduction Receptor tyrosine kinases (RTKs) are critically involved in the development and progression of human cancers and are therefore useful targets for anti-cancer therapies [1]. The Eph receptors represent the largest subfamily of receptor protein kinases and interact with ligands called

• Another interesting finding regarding substrate selectivity

  2021-03-15

  

  Another interesting finding regarding substrate selectivity of iPLA2-VIA in whole cellular systems stems from the observation that some of the major species hydrolyzed by the enzyme contain a 16:1 fatty adrenoceptor at the sn-2 position [57,119], raising the possibility that iPLA2-VIA may constitut

• Phenolic compounds generated during biomass

  2021-03-15

  

  Phenolic compounds generated during 175 pretreatment inhibit and/or deactivate cellulolytic/hemicellulolytic enzymes as well as the viability and fermentative capacity of yeast and bacteria [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]. Phenolic compounds cause changes in protein conformatio

• It is known that cigarette smoke increases

  2021-03-15

  

  It is known that cigarette smoke increases the oxidative burden in the lungs of mice with emphysema, which leads to oxidative stress [[34], [35], [36]]. However, in addition to cigarette smoke, studies have shown that endogenous oxidative stress is associated with proteolytic pregnane x receptor in

• DGK is a key enzyme in glucose uptake

  2021-03-15

  

  DGKδ is a key enzyme in glucose uptake in skeletal muscle. Chibalin et al. demonstrated that a decrease in DGKδ expression increases the severity of type 2 diabetes [20]. Additionally, DGKδ expression was increased in people who exhibited enhanced insulin sensitivity after exercise training [56]. Fr

• In conclusion DDR ECD was shown to

  2021-03-15

  

  In conclusion, DDR1 ECD was shown to be sufficient for collagen mediated DDR1 oligomerization, and the oligomerized form binds to collagen with increased affinity. In full length receptors expressed on live cells, DDR1 oligomerization occurred on the cell surface in agreement with the role of DDR1 E

• Oseltamivir phosphate Here two labs that helped characterize

  2021-03-13

  

  Here, two labs that helped characterize these two pathways have worked together to further test whether these apparently parallel pathways from β-AR to CaMKII-RyR might be related in series. Much of the work leading to the Epac pathway involved measurement of Ca sparks as an index of SR Ca leak, oft

• The role of ETB clearing

  2021-03-13

  

  The role of ETB clearing receptors has been studied in detail in endothelial cell–specific ETB knock-out mice. In these animals, clearance of an intravenous Pranlukast mg of labeled ET-1 was reduced significantly compared with wild-type controls. Importantly, functioning ETB were retained on all oth

• br Acknowledgements br Introduction Supramolecular

  2021-03-13

  

  Acknowledgements Introduction Supramolecular collagen assemblies are crucial for the mechanical stability of animal bodies (Myllyharju and Kivirikko, 2004). The basic collagen structure is a triple helix of three chains containing multiple Gly-X-X' repeats; X and X' are often proline and 4-hyd

• In conclusion our results provide a new mechanistic insight

  2021-03-13

  

  In conclusion, our results provide a new mechanistic insight into the signaling pathways mediating TDCIPP-induced apoptosis in cultured neuronal cells. We showed that TDCIPP-induced neuronal cell cytotoxicity and death are mediated via the ER stress-regulated apoptotic pathway, wherein the induction

• To elucidate whether the impact of hypoxia

  2021-03-13

  

  To elucidate whether the impact of hypoxia on EGFR expression is cell context specific or culturing density dependent, we chose the following cancer Deoxycholic acid sale driven by EGFR and evaluated the EGFR expression after hypoxia treatment at different culturing density: a highly aggressive and

11061 records 379/738 page Previous Next First page 上5页 376377378379380 下5页 Last page