• Several studies have demonstrated that Syn specifically asso

  2020-07-11

  

  Several studies have demonstrated that αSyn specifically associates with lipid rafts (Cole et al., 2002), raising the possibility that the perturbation of rafts can affect the aggregation and phosphorylation of αSyn (Fortin et al., 2004). Schneider et al. (2010) described the potential involvement o

• br Oxysterols as Key Players in Metabolic Syndrome Obesity a

  2020-07-11

  

  Oxysterols as Key Players in Metabolic Syndrome? Obesity and sedentary lifestyle are on the rise and pose serious threats to people\'s health and wellbeing. Obesity is often associated with other pathologies and is one of the criteria included in the definition of metabolic syndrome (MetS) (see G

• br Acknowledgments Grant support was provided by

  2020-07-11

  

  Acknowledgments Grant support was provided by the Leading Academic Discipline Projects of Shanghai Municipal Education Commission (J5028) (J50201) to Dr. Mi, the China National Science Foundation Project (81072076) to Dr. Mi, the China National Science Foundation Project (31000349) to Dr. Shen, a

• br RING dimerization RING type

  2020-07-10

  

  RING dimerization RING-type domains are found in many different structural contexts. While many exist as single-chain d luciferin synthesis (Fig. 3A), a notable feature of RING-type E3s is their tendency to form homodimers and heterodimers (Fig. 3C–F). Homodimeric RING-type E3s include cIAP, RNF

• Opiate withdrawal promotes the activation of the corticotrop

  2020-07-10

  

  Opiate withdrawal promotes the activation of the corticotropin-releasing factor (CRF) system, a major coordinator of neuroendocrine and behavioral responses to stressors. For instance, early (8–48 h) morphine withdrawal is associated with increased CRF mRNA expression in the central nucleus of the a

• In recent years neuroimaging studies have increasingly demon

  2020-07-10

  

  In recent years, neuroimaging studies have increasingly demonstrated acute effects of THC on Ac-DEVD-AFC australia function, the vast majority of them involving a cognitive challenge (Bossong et al., 2014b). For example, without affecting performance accuracy, THC caused reductions in activity duri

• Over the last decade numerous studies

  2020-07-10

  

  Over the last decade, numerous studies have evaluated the acute, short-term, and medium-term impact of pulmonary vasodilators on Fontan physiology.23., 24., 25., 26., 27., 28., 29., 30., 31. Although different trilithium of medications have been evaluated, phosphodiesterase-5 (PDE-5) inhibitors hav

• Our comparison of all ER iso forms with

  2020-07-10

  

  Our comparison of all ERα (iso)forms with ERβ immunostaining suggests that overall ERβ expression is lower than that of ERα isoforms. This contrasts the so far reported data for ERs in the lung, but is not a paradox; in pathology routine, ER positivity is defined stricto senso by nuclear WT ERs. As

• br Physiological roles for EPAC isoforms vascular

  2020-07-10

  

  Physiological roles for EPAC isoforms: vascular function The effects of cAMP on limiting vascular endothelial cell (VEC) inflammation and vascular smooth muscle cell (VSMC) proliferation have been well documented 36, 37, 38. However, recent work has demonstrated that several key effects of cAMP i

• Several molecular differences between visceral and subcutane

  2020-07-10

  

  Several molecular differences between visceral and subcutaneous adipose tissue have been described. One of the most demarcating differences between adipose depots is the signature of developmental genes, including Hox, Shox, and T-box genes [12], [13]. Lineage tracing studies have revealed key devel

• Cryoprotectant equilibration and the response to ice concent

  2020-07-09

  

  Cryoprotectant equilibration and the response to ice concentrated media are the two facets of cellular cryobiological protocols most commonly covered by mathematical modeling. In these models, 49 9 are typically assumed to have uniform, spatially independent extracellular concentrations and tempera

• Hydrocortisone br Discussion The present results demonstrate

  2020-07-09

  

  Discussion The present results demonstrate that high dose estrogen–progestogen OC treatment produced impaired glucose tolerance and glucose tolerance was preserved during low dose estrogen–progestogen, high or low dose progestogen-only OC use. The study also shows that impaired glucose tolerance

• In our former work our interest

  2020-07-09

  

  In our former work, our interest was in discovery of novel VEGFR-2 inhibitors as anti-angiogenesis agents. Along this line, with natural alkaloid taspine as the lead compound, rounds of structure optimization were performed to develop novel VEGFR-2 inhibitors [[13], [14], [15]]. Among them, BPS-7, b

• It is believed that emphysema in smokers is mediated

  2020-07-09

  

  It is believed that emphysema in smokers is mediated by proteases released from inflammatory GS-9350 that cause destruction of the extracellular matrix in alveolar septa [1]. Metalloprotease-12 is mainly released by macrophages and is considered the enzyme responsible for emphysematous lesions in ex

• In addition to grouping cases of B ALL by

  2020-07-09

  

  In addition to grouping cases of B-ALL by cell of origin, these lymphomas can also be subcharacterized by genetic rearrangements. Fusion of the purinergic receptor P2RY8 promoter to the CRLF2 (cytokine receptor like factor 2) gene frequently occurs in B-ALL but reports of the functional consequences

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