• The combination therapy was exceedingly well tolerated witho

  2019-04-30

  

  The combination therapy was exceedingly well tolerated without any side effects to either drug. Remarkably, despite an advanced PV-stage the JAK2V617F allele burden was rapidly lowered from 90% mutated Wnt agonist 1 at referral to 59% at 6 months, 28% at 10 months and 12% at 16 months of therapy (F

• For many decades scientists have warned

  2019-04-30

  

  For many decades, scientists have warned that human activity is pushing life on our planet beyond the point of no return. In the Earth\'s history there have been five mass extinction events, most recently the Cretaceous–Tertiary mass extinction that occurred almost 65 million years ago and was thoug

• External resources still account for of total health spendin

  2019-04-29

  

  External resources still account for 16·4% of total health spending in low-income countries and 9·5% in countries in Africa. This finding has implications for the sustainability and fungibility of programmes and is vital to better understand the trend of the sources and level of supports. Despite a

• Sin embargo los movimientos sociales brasile os y

  2019-04-29

  

  Sin embargo, los movimientos sociales brasileños y argentinos analizados no asumen una negación absoluta de la política y lo político, desde una supuesta condición puramente social. En este caso, si bien subrayan su vocación de no tomar parte en las dinámicas generales de la política tradicional (co

• Soofi and colleagues Article has also highlighted the danger

  2019-04-29

  

  Soofi and colleagues\' Article has also highlighted the dangers of developing interventions built on hypothetical assumptions that do not take evidence and on-the-ground realities into account. A common oversight in programme design is failure to account for local contextual sociocultural values and

• imidazoline Lithium is widely used to treat depression and

  2019-04-29

  

  Lithium is widely used to treat depression and bipolar disorder. The lithium-induced BrS phenotype is not common, but it can be observed even with use of therapeutic dosages [49]. Lithium also causes other conduction dysfunctions such as sinus node dysfunction, conduction block, and ventricular arrh

• LXR signaling has also been shown to regulate inflammation a

  2019-04-29

  

  LXR signaling has also been shown to regulate inflammation and fibrosis within the liver. We cannot exclude the possibility that the anti-inflammatory and anti-fibrotic activities of LXR may have also contributed to the protective effect of STS. Indeed, we have previously reported that the expressio

• br Methods br Results Globally CCI increased by percent

  2019-04-28

  

  Methods Results Globally, CCI increased by 0·82 percent points a year, from 54·8% in 1994, to 71·2% in 2014 (CCI estimates at national level, stratified by wealth quintiles and place of residence, are presented in the appendix, pp 6–15). This gain was largely driven by low-income countries, wh

• Postoperatively we increased the dose of

  2019-04-28

  

  Postoperatively, we increased the dose of propranolol to 45mg/day. Atrial pacing and ventricular sensing to 80beats/min were observed all day. TdP and T-wave alternans disappeared with a shorter QT interval (Fig. 1c). Remote monitoring of the device revealed no recurrence of TdP or ICD shock. Dis

• Huelga decir que el tono encomi stico de estos elogios

  2019-04-28

  

  Huelga decir que el tono encomiástico de estos elogios convirtió Alvespimycin este género en una tipología discursiva algo maniquea, abrumada por los abusos retóricos y laudatorios. Se trataba tanto de exhibir una trayectoria vital consagrada a la ciencia, como de hacerlo empleando un registro estet

• br Conflict of interests br Introduction

  2019-04-28

  

  Conflict of interests Introduction Recently Zhou et al. developed the new National Comprehensive Cancer Network (NCCN)- International Prognostic Index (IPI) to predict survival in the rituximab era more accurately than the older IPI system [1]. Although reports that used the same prognostic st

• Katherine Semrau and colleagues did a cluster randomised con

  2019-04-28

  

  Katherine Semrau and colleagues did a cluster-randomised controlled trial in Southern Province, Zambia. Fieldworkers visited women antenatally within 24 h of delivery, and repeatedly during the newborns\' first month of life. Families in the intervention group were given 4% chlorhexidine solution to

• In subgroup analysis of the types of hospice as

  2019-04-28

  

  In subgroup analysis of the types of hospice as classified by the administrative authorities (Table 3), there was a trend that the patients admitted to a public hospital had a higher rate of dying in a hospice than those admitted to a private hospital, especially in the military and veterans\' hospi

• Racial ethnic differences should also be considered for the

  2019-04-28

  

  Racial/ethnic differences should also be considered for the effects of ASA. In the JAST (Japan Atrial Fibrillation Stroke Trial) in 896 Japanese patients with nonvalvular AF [22], the incidence of the primary composite endpoint (i.e., cerebral infarction, TIA, or cardiovascular death) was higher in

• In summary programmed long AVD prolonged

  2019-04-28

  

  In summary, programmed long AVD, prolonged VA conduction time caused by anti-arrhythmic medication, and the rate of ELT (110bpm, below the upper tracking rate of 120bpm) were the reason ELT continued even in the presence of a programmed ELT termination algorithm. Physicians who manage patients with

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